A thorough understanding of the role of lncRNA in prostate cancer pathogenesis; Current knowledge and future research directions

Ramin Haghighi, Roxana Yolanda Castillo-Acobo, Ali H Amin, Hadi Mohammed Ehymayed, Farah Alhili, Mojgan Mirzaei, Saman Mohammadzadeh Saliani, Hadis Kheradjoo

Research output: Contribution to journalReview articlepeer-review

Abstract

In the entire world, prostate cancer (PCa) is one of the most common and deadly cancers. Treatment failure is still common among patients, despite PCa diagnosis and treatment improvements. Inadequate early diagnostic markers and the emergence of resistance to conventional therapeutic approaches, particularly androgen-deprivation therapy, are the causes of this. Long non-coding RNAs (lncRNAs), as an essential group of regulatory molecules, have been reported to be dysregulated through prostate tumorigenesis and hold great promise as diagnostic targets. Besides, lncRNAs regulate the malignant features of PCa cells, such as proliferation, invasion, metastasis, and drug resistance. These multifunctional RNA molecules interact with other molecular effectors like miRNAs and transcription factors to modulate various signaling pathways, including AR signaling. This study aimed to compile new knowledge regarding the role of lncRNA through prostate tumorigenesis in terms of their effects on the various malignant characteristics of PCa cells; in light of these characteristics and the significant potential of lncRNAs as diagnostic and therapeutic targets for PCa. Availability of data and materials: Not applicable.

Original languageEnglish
Article number154666
JournalPathology Research and Practice
Volume248
DOIs
StatePublished - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023

Keywords

  • Drug resistance
  • LncRNAs
  • Metastasis
  • Prostate cancer

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