Dementia in Latin America: Paving the way toward a regional action plan

Mario Alfredo Parra, Sandra Baez, Lucas Sedeño, Cecilia Gonzalez Campo, Hernando Santamaría-García, Ivan Aprahamian, Paulo H.F. Bertolucci, Julian Bustin, Maria Aparecida Camargos Bicalho, Carlos Cano-Gutierrez, Paulo Caramelli, Marcia L.F. Chaves, Patricia Cogram, Bárbara Costa Beber, Felipe A. Court, Leonardo Cruz de Souza, Nilton Custodio, Andres Damian, Myriam de la Cruz, Roberta Diehl RodriguezSonia Maria Dozzi Brucki, Lais Fajersztajn, Gonzalo A. Farías, Fernanda G. De Felice, Raffaele Ferrari, Fabricio Ferreira de Oliveira, Sergio T. Ferreira, Ceres Ferretti, Marcio Luiz Figueredo Balthazar, Norberto Anizio Ferreira Frota, Patricio Fuentes, Adolfo M. García, Patricia J. Garcia, Fábio Henrique de Gobbi Porto, Lissette Duque Peñailillo, Henry Willy Engler, Irene Maier, Ignacio F. Mata, Christian Gonzalez-Billault, Oscar L. Lopez, Laura Morelli, Ricardo Nitrini, Yakeel T. Quiroz, Alejandra Guerrero Barragan, David Huepe, Fabricio Joao Pio, Claudia Kimie Suemoto, Renata Kochhann, Silvia Kochen, Fiona Kumfor, Serggio Lanata, Bruce Miller, Leticia Lessa Mansur, Mirna Lie Hosogi, Patricia Lillo, Jorge Llibre Guerra, David Lira, Francisco Lopera, Adelina Comas, José Alberto Avila-Funes, Ana Luisa Sosa, Claudia Ramos, Elisa de Paula França Resende, Heather M. Snyder, Ioannis Tarnanas, Jenifer Yokoyama, Juan Llibre, Juan Felipe Cardona, Kate Possin, Kenneth S. Kosik, Rosa Montesinos, Sebastian Moguilner, Patricia Cristina Lourdes Solis, Renata Eloah de Lucena Ferretti-Rebustini, Jeronimo Martin Ramirez, Diana Matallana, Lingani Mbakile-Mahlanza, Alyne Mendonça Marques Ton, Ronnielly Melo Tavares, Eliane C. Miotto, Graciela Muniz-Terrera, Luis Arnoldo Muñoz-Nevárez, David Orozco, Maira Okada de Oliveira, Olivier Piguet, Maritza Pintado Caipa, Stefanie Danielle Piña Escudero, Lucas Porcello Schilling, André Luiz Rodrigues Palmeira, Mônica Sanches Yassuda, Jose Manuel Santacruz-Escudero, Rodrigo Bernardo Serafim, Jerusa Smid, Andrea Slachevsky, Cecilia Serrano, Marcio Fernando Soto Añari, Leonel Tadao Takada, Lea Tenenholz Grinberg, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Dominic Trépel, Agustin Ibanez

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

Original languageEnglish
Pages (from-to)295-313
Number of pages19
JournalAlzheimer's and Dementia
Volume17
Issue number2
DOIs
StatePublished - Feb 2021
Externally publishedYes

Bibliographical note

Funding Information:
The Expert Meeting was supported by Alzheimer's Society UK grants awarded to MP in collaboration with AI (AS‐R42303, AS‐SF‐14‐008). AS is supported by CONICYT / FONDAP /15150012; Conicyt/ Fondecyt Regular/ 1140423 and Basal Funds for Centers of Excellence, Project FB 0003 from the Associative Research Program of CONICYT. FL is supported by a grant API COLOMBIA funded by GENENTECH and Banner Institute. FK is supported by a National Health and Medical Research Council of Australia (NHMRC)‐Australian Research Council Dementia Research Development Fellowship (APP1097026). OP is supported by an NHMRC Senior Research Fellowship (APP1103258). FFDO is supported by FAPESP ‐ The State of São Paulo Research Foundation (grant #2015/10109‐5). The support from Alzheimer´s Scotland Dementia Research and the Centre for Cognitive Ageing and Cognitive Epidemiology part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1) both from the University of Edinburgh is also acknowledged. FS is supported by Geroscience Center for Brain Health and Metabolism (FONDAP‐15150012) and Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT, No. 1150766). RAV is supported by CONICYT AFB 170008 and by Faculty of Sciences, University of Chile, PAIFAC grant. PC is supported by CNPq, Brazil (bolsa de produtividade em pesquisa). PL is supported by FONDAP Program Grant 15150012 & by Conicyt/Fondecyt Regular/ 1160940. STF is supported by National Institute for Translational Neuroscience (Brazil, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ/Brazil). BCB is supported by Alzheimer's Association and Global Brain Health Institute (GBHI_ALZ‐18‐542347). LTG is supported by NIH K24AG053435. MLFC is supported by CNPq (bolsa de produtividade em pesquisa). RDR is supported by FAPESP (2016/24326‐0) and the Alzheimer´s Association (AARF‐18‐566005). LD is partially supported by Neuromedicenter. RF is supported by Alzheimer's Society (grant # 284). LCS is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil). MSY is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil) and São Paulo Research Foundation (FAPESP/BRAZIL). MACB is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil) and Minas Gerais Research Foundation (FAPEMIG/BRAZIL). IA receives National public grant level 2 from the National Council for Scientific and Technological Development (Ministry of Science, Technology, Innovation and Communications, Brazil). HMS is a full‐time employee of the Alzheimer's Association. AI is partially supported by grants from CONICET, FONCyT‐PICT 2017‐1818, FONCyT‐PICT 2017‐1820, FONDAP 15150012, the Interamerican Development Bank (IDB), Alzheimer's Association GBHI ALZ UK‐20‐639295, and the MULTI‐PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by National Institutes of Health, National Institute on Aging (R01 AG057234), Alzheimer's Association (SG‐20‐725707), Tau Consortium, and Global Brain Health Institute)]. The contents of this publication are solely the responsibility of the authors and do not represent the official views of these Institutions. The other authors declare no conflict of interests.

Funding Information:
The authors thank Laura Bleiler from the Alzheimer's Association (AA) for proofreading the article. The authors also thank the Inter‐American Development Bank (IDB) and the the MULTI‐PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by National Institutes of Health, National Institutes of Aging (R01 AG057234), Alzheimer's Association (SG‐20‐725707), Tau Consortium, and Global Brain Health Institute] and the grant Alzheimer's Association GBHI ALZ UK‐20‐639295. The contents of this publication are solely the responsibility of the authors and do not represent the official views of these institutions.

Publisher Copyright:
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.

Keywords

  • Latin America
  • biomarkers
  • clinical trials
  • dementia
  • epidemiology
  • evidence-based recommendations
  • genetics
  • knowledge to action framework
  • networking and translational research
  • nonpharmacological interventions

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