Efecto de la oxitocina en los niveles de malondialdehído, óxido nítrico y proteína S100B en el recién nacido

Translated title of the contribution: Effect of oxytocin on the levels of malondialdehyde, nitric oxide, and S100B protein in Newborns

Dante Condori-Merma, Oscar Moreno-Loaiza, Azael Paz-Aliaga, José Barrionuevo-Rodríguez

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives. To assess the effects of the administration of oxytocin during labor management on the levels of malondialdehyde (MDA), nitric oxide (NO), and S100B protein in newborns. Materials and Methods. We selected 80 term pregnant women without obstetric and fetal pathology, forming two groups: pregnant women with normal delivery and pregnant women conducted with oxytocin. Blood was collected immediately after delivery from the umbilical cord vein to measure MDA, ON and from the artery for protein S100B. The concentration of MDA and ON was quantified by spectroscopic methods and the protein S100B by ELISA. Results. Values of 3.4 uMol/L and 3.6 uMol/L of MDA and 1.4 uMol/L and 1.8 uMol/L of NO were obtained in the oxytocin and control group, respectively, without significant difference; S100B levels were higher in the oxytocin managed group, with a median of 1.36 μg/L compared to the normal delivery group 1.11 μg/L (p=0.03). There was no relationship between the dose of oxytocin administered and the levels of MDA, ON, and S100B. Conclusions. There is no difference between MDA and NO levels between pregnant women undergoing a normal or managed birth. There is a significant difference in S100B protein levels in newborns born via an oxytocin-managed delivery. There is no relationship between oxytocin dose and levels of oxidative stress and S100B protein.

Translated title of the contributionEffect of oxytocin on the levels of malondialdehyde, nitric oxide, and S100B protein in Newborns
Original languageSpanish
Pages (from-to)449-455
Number of pages7
JournalRevista Peruana de Medicina de Experimental y Salud Publica
Volume35
Issue number3
DOIs
StatePublished - 1 Jul 2018

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© 2018, Instituto Nacional de Salud. All rights reserved.

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