Niveles de anticuerpos de Treponema palidium en adultos mayores peruanos deteriorio cognitivo no amnésico leve en convivencia comunitaria

Translated title of the contribution: Treponema pallidum antibody levels in Peruvian older adults with memory complaints and mild cognitive impairment in community living

Roxana Castillo-Acobo, Norman Darío L. Velásquez, Brenda Nadia Chino Vilca

Research output: Contribution to journalArticlepeer-review

Abstract

Syphilis (Treponema pallidum) is a chronic disease acquired by direct contact, generally sexual, with active primary or secondary lesions. The World Health Organization estimates that 12 million new cases of syphilis occur each year. The vast majority of these are seen in developing countries. Humans are initially infected primarily at the anogenital level; however, the eruption of secondary syphilis is a clear indication that the organisms are spreading widely from the primary site of contact. In addition to the above, syphilis has also been associated with mild cognitive impairment (NAMCI). The objective of this work was to determine the cognitive performance of healthy older adults (AM) in a community in Peru with mild memory problems that affected their condition. To this end, 574 AM were evaluated using the Mental State (MMSE) and Geriatric Depression (Yesavage) tests. Of the 574 elderly, 74 adults with mild non-amnestic cognitive impairment due to their account or history of venereal disease course and at least one positive VRDL test were included. The weighted general seroprevalence of antitreponemal antibodies in the study population was 32.43% (95% CI 21.091-41.774), with 100% correspondence between the VTDL and MHA-Tp tests in older adults and naMCI with a history of disease course. venereal or reactive VRDL test. When reviewing the sociodemographic and clinical characteristics of the study groups, it was observed that the subjects had a high level of education, had no family history, and exhibited few diseases.

Translated title of the contributionTreponema pallidum antibody levels in Peruvian older adults with memory complaints and mild cognitive impairment in community living
Original languageSpanish
Pages (from-to)411-420
Number of pages10
JournalBoletin de Malariologia y Salud Ambiental
Volume63
Issue number2
DOIs
StatePublished - Mar 2023

Bibliographical note

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© 2023 Instituto de Altos Estudios de Salud Publica. All rights reserved.

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