The objective of the study was to identify the types of studies and the most investigated topics in the population with Down syndrome in Chile and to describe the type of sample used and the age range during the period from 2011 to 2020. A documentary study was carried out (systematic review). The Scopus database was used to search for information. The key words used were: Down Syndrome and Chile. The period was 2011 to 2020. The information was recorded on an observation sheet. Thirty studies were identified. A total of 56,7 % (n = 17) were descriptive (cross-sectional) studies, 10,0 % (n = 3) were experimental studies. The study topics mostly cover social issues (8 studies) and anthropometric aspects (7 studies), followed by physiological, psychological, hematological, biomechanical, prenatal tests and sleep disorders. The age range of the sample used by the studies ranges from prenatal to 28 years and the sample size ranges from one to 1922 participants. The results of the study suggest the urgent need to develop experimental and longitudinal studies, the inclusion of middle-aged and older adults, as well as prenatal samples, to explore issues related to physiological, psychological, hematological, biomechanical variables and prenatal diagnostic tests, since they are relevant to the independence and autonomy of people with Down syndrome.
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