A new mulinane diterpenoid from the cushion shrub Azorella compacta growing in Perú

Francisco Salgado, Carlos Areche, Beatriz Sepúlveda, Mario J. Simirgiotis, Fatima America Caceres De Baldarrago, Cristina Quispe, Lina Graciela Quispe Quispe, Teresa Cano

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

10 Citas (Scopus)

Resumen

Background: Azorella compacta is a rare yellow-green compact resinous cushion shrub growing from the high Andes of southern Peru to northwestern Argentina, and which is a producer of biologically active and unique diterpenoids. Objective: This study investigated the secondary metabolites present in a Peruvian sample of Azorella compacta and the evaluation of gastroprotective activity of the isolated compounds in a gastric- induced ulcer model in mice. Material and Methods: Six secondary metabolites (diterpenoids 1-6) present in the dichloromethane (DCM) extract of A. compacta growing in Peru were isolated by a combination of Sephadex LH-20 permeation and silica gel chromatography and their chemical structures were elucidated by spectroscopic methods (NMR) and molecular modeling. The gastroprotective activity of the new compound 1 was evaluated on the HCl/EtOH-induced gastric lesion model in mice and compared to the activity showed by the known compounds. Results: A new mulinane diterpene along with five known diterpenoids have been isolated from a Peruvian sample of A. compacta and the gastroprotective results show that compound 1 is less active than the other known mulinane diterpenoids isolated. Conclusions: A. compacta growing in Peru showed the presence of the new mulinane 1, which was poorly active in the HCl/EtOH-induced gastric lesion model in mice. Indeed, the activity was lower than other diterpenoids (2-6) showing an oxygenated function at C-16 or/and C-20, which confirm the role of an oxygenated group (OH or carboxylic acid) for the gastroprotective activity of mulinane compounds.

Idioma originalInglés
Páginas (desde-hasta)S543-S548
PublicaciónPharmacognosy Magazine
Volumen10
N.º39
DOI
EstadoPublicada - 1 jul. 2014

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